Scalable quantum information systems would store, manipulate, and transmit quantum information locally and across a quantum network, but no single qubit technology is currently robust enough to perform all necessary tasks. Defect centers in solid-state materials have emerged as potential intermediaries between other physical manifestations of qubits, such as superconducting qubits and photonic qubits, to leverage their complementary advantages. It remains an open question, however, how to design and to control quantum interfaces to defect centers. Such interfaces would enable quantum information to be moved seamlessly between different physical systems. Understanding and constructing the required interfaces would, therefore, unlock the next big steps in quantum computing, sensing, and communications. In this Perspective, we highlight promising coupling mechanisms, including dipole-, phonon-, and magnon-mediated interactions, and discuss how contributions from nanotechnologists will be paramount in realizing quantum information processors in the near-term.